From Molecules to Cells
We use a large array of techniques to create a powerful set of tools to explore our questions from the molecule to humans. Our perspective is that in vitro experiments are necessary to isolate parameters and offer a molecular resolution difficult to achieve in vivo. In vivo experiments provide a physiological and integrated perspective where we can take into account all elements of the neurovascular unit and the interactions between different systems within an organism. We also combine transgenic mice and pharmacological approaches to test therapeutic targets and molecular pathways. Finally, our non invasive research in humans offers a translational platform to test our hypothesis provided by fundamental research. In turn, data derived from clinical studies gives insights about experimental models to develop as well as therapeutical targets to study.